1-boc Piperazine

[samir gondaliya]

Introduction

1-Boc Piperazine is a widely used chemical intermediate in pharmaceutical research, known for its role in the synthesis of a wide variety of bioactive molecules. The compound features a piperazine ring protected by a Boc (tert-butoxycarbonyl) group, which enhances its stability and selectivity in multi-step synthetic procedures.

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Chemical Identity

• IUPAC Name: 1-(tert-Butoxycarbonyl)piperazine

• CAS Number: 57260-71-6

• Molecular Formula: C9H18N2O2

• Molecular Weight: 186.25 g/mol

• Appearance: White to off-white crystalline powder

• Solubility: Soluble in common organic solvents such as dichloromethane, methanol, and acetonitrile

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Structural Features

1-Boc Piperazine consists of a six-membered piperazine ring, where one nitrogen is protected with a tert-butoxycarbonyl (Boc) group. This protection:

• Enhances the selective functionalization of the second nitrogen

• Provides stability under basic conditions

• Is easily removed under acidic conditions, making it ideal for stepwise synthesis

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Applications of 1-Boc Piperazine

1. Pharmaceutical Intermediate

It is a key building block in the synthesis of several classes of drugs, including:

• Antipsychotics

• Antidepressants

• Anti-inflammatory agents

• Anti-cancer compounds

The Boc group allows for temporary protection during multi-step synthesis, enabling the development of diverse heterocyclic scaffolds.

2. Medicinal Chemistry and Drug Discovery

1-Boc Piperazine is commonly used in combinatorial chemistry and lead optimization, offering:

• Increased lipophilicity

• Improved pharmacokinetic properties

• Potential for receptor binding enhancement

3. Custom Peptidomimetic Synthesis

In the design of peptidomimetics, 1-Boc Piperazine serves as a flexible spacer or scaffold that mimics peptide bonds, useful in:

• Enzyme inhibitors

• Signal transduction mimics

• Receptor ligands

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Handling and Safety

• Hazards: May cause skin or eye irritation

• Precautions: Handle with gloves and eye protection; avoid inhalation or prolonged exposure

• Storage Conditions: Store in a tightly sealed container, in a cool, dry place away from acids

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Packaging and Supply

Available in:

• Small Packs: 5g, 25g, 100g for research use

• Bulk Quantities: 1kg, 5kg, and custom volumes for commercial production

Supplied with COA, MSDS, and global shipping options.

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Conclusion

1-Boc Piperazine is a cornerstone intermediate in the field of organic and medicinal chemistry. Its versatility, ease of use, and clean deprotection make it a preferred choice for researchers and manufacturers developing advanced drug candidates and custom molecules.

Need bulk or custom-packed 1-Boc Piperazine? Contact us for quotations, technical documentation, and application support tailored to your R&D or production goals.