Sport Blue 6s for sale PubMed Pautler EL

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Methods SpragueDawley rats reared under cyclic light were exposed continuously to diffuse blue light (400480 nm) at 0.64 W/m2 for 3 or 6 h after 22 h of dark adaptation. The rats were kept in darkness and killed immediately, 8,16 and 24 h following light exposure. The retinal damage by the blue light was examined with a transmission electron microscope. The cell death was characterised by in situ terminal dUTP nick end labelling (TUNEL) and gel electrophoresis.Results During the 24 h following light exposure, photoreceptor cell death was characterised by progressive condensation and margination of the chromatin, shrinkage cheap Sport Blue 6s or convolution and fragmentation of the nucleus, condensation of the cytoplasm, and formation of apoptotic bodies along with rapid removal of dying cells from damaged areas in the absence of inflammatory response. The TUNELpositive nuclei were scattered individually in the outer nuclear layer just after light exposure. A wave of massive TUNEL labelling of photoreceptor nuclei peaked at 816 h and dropped at 24 h following light exposure. The distribution of TUNELpositive nuclei was located predominantly at the upper temporal region of the retina, which was the most sensitive area to the damage caused by blue light. Furthermore, the multiples of internucleosomal cleavage of 180200 base pairs were demonstrated at corresponding time points.Conclusion Photoreceptor cell apoptosis is seen early after the retina is damaged by blue light.Keywords: Apoptosis; Blue light; Cell death; Light damage; RetinaTop of pageReferencesNoell WK, Walker VS, Kang BS, Berman S. Retinal damage by light in rats. Invest Ophthalmol 1966; 5: 450 PubMed ChemPort Ham WT Jr, Mueller HA, Sliney DH. Retinal sensitivity to damage from short wavelength light. Nature 1976; 260: 153 Article PubMed ISI Ham WT Jr, Mueller HA, Ruffolo JJ Jr, Clarke AM. Sensitivity of the retina to radiation damage as a function of wavelength. Photochem Photobiol 1979; 29: 735 Article PubMed ISI Young RW. Pathophysiology of agerelated macular degeneration.

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