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Opana ER (oxymorphone hydrochloride extended-release) was a prescription opioid medication used for the management of severe, chronic pain in patients who required continuous, long-term opioid treatment. The 5 mg dosage represented the lowest strength of the extended-release formulation, often used as a starting point for opioid-tolerant patients or those being converted from other pain medications. The active ingredient, oxymorphone, is a semi-synthetic opioid derived from thebaine, a component of the opium poppy. It is chemically related to morphine and hydromorphone but is notably more potent than morphine. Opana ER was designed to deliver 12-hour sustained pain relief, making it appropriate for conditions like cancer pain, neuropathic pain, or post-surgical recovery in select cases.

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