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NASHVILLE -- The San Francisco 49ers know how to start a very long road trip in winning style. Sebastian Janikowski White black Jersey . Colin Kaepernick threw for 199 yards and ran for 68 and a touchdown, helping the 49ers start a two-game road swing by beating the Tennessee Titans 31-17 Sunday. The 49ers (5-2) won their fourth straight before heading to London for a game with winless Jacksonville by jumping to a 17-0 halftime lead. Frank Gore also ran for a pair of 1-yard TDs as San Francisco cruised. "This was a big game, and we were treating it like the biggest game of the season," 49ers coach Jim Harbaugh said. "It was our next game. This was Game 7 for us, and we were treating it like Game 7 for us, and we were treating it like Game 7 of the World Series or Game 7 of the Stanley Cup. Now the next game will be Game 8." Tramaine Brock also intercepted a pass, Justin Smith had two of the 49ers three sacks and Kassim Osgood recovered a muffed punt for a TD. The Titans (3-4) lost their third straight even with Jake Locker starting after missing two games with a sprained right hip and knee. Locker threw for 326 yards, with two TD passes in a fourth-quarter spurt that came up short. Coach Mike Munchak defended the decision to start Locker, saying the quarterback was ready. Locker also ran three times for 29 yards. "We felt comfortable hed be able to protect himself," Munchak said. "I think he showed he could do that." The Titans outgained the 49ers 368-349 in total offence only because of a frantic fourth quarter as they tried to rally. San Francisco still had a big edge in time of possession, holding the ball for more than 35 minutes, including the third quarter when the 49ers played keepaway for more than 11 minutes. Gore capped the opening drive of the third with his second TD for a 24-0 lead. "I dont know how you define midseason form, but we have strung together a few wins and we feel pretty good about what were doing right now," Kaepernick said. Tennessee tried to make it interesting late in a finish that featured plenty of pushing and shoving. Even Harbaugh got an arm caught up in a scrum on the San Francisco sideline after Kaepernick dived in trying to recover what he and the Titans thought was a fumble. "I was just trying to get them apart," Harbaugh said. Locker tossed a short pass to Chris Johnson for a 66-yard TD, pulling Tennessee within 24-10 with 7:07 left, and the Titans forced the 49ers to punt. But Tommie Campbell blocked Darryl Morris into Darius Reynaud, who muffed the punt. Osgood recovered in the end zone for the clinching TD. Locker found former 49ers tight end Delanie Walker on a 26-yard TD with 3:17 left. The Titans were offside on the ensuing onside kick, and the 49ers recovered to run out the clock. The 49ers were in control from the start with plenty of fans on hand, and they took advantage of Tennessees 10 penalties for 100 yards. The most costly came when linebacker Akeem Ayers hit Kaepernick at the knees for an unnecessary roughness flag that wiped out an interception by safety Bernard Pollard. Three plays later, Kaepernick ran 20 yards for a TD and a 10-0 lead. The Titans held Gore to 70 yards rushing on 24 carries, but he got into the end zone twice. They could not stop Kaepernick, who repeatedly kept drives alive in improving to 12-5 as a starter. "He continues to get better every game since hes been playing," Harbaugh said. "He got a game ball last week and I thought he was very effective today both running and throwing. I cant say enough good things about him." Locker hadnt been expected back before Nov. 3, when the Titans visit St. Louis after their bye. Playing with a knee brace, he hit seven of his first 10 passes for 80 yards. His best run was 16-yarder giving the Titans first-and-goal early in the fourth quarter when Locker put his head down diving forward. They wound up settling for a field goal. "We found ways to stall drives out," Locker said. "I didnt think it was really us getting going. Weve got to find ways to do that." But Brock picked off an underthrown ball for the quarterbacks first interception this season. The 49ers quickly converted that into a 1-yard TD run by Gore for a 17-0 lead just before halftime. Notes: Brock now has three interceptions in three games. ... The 49ers now lead this series 8-5. ... The Titans had a video tribute to the late Bum Phillips and a moment of silence before the coin toss. Phillips coached this franchise to two AFC championship game appearances in the late 1970s as the then-Houston Oilers. ... Johnson now has three TD catches of 66 yards or longer and 11 TDs of 66 yards or longer in his career. Khalil Mack Impact Jersey . Its sharpness matched my mind. This was no night to go to sleep. Sebastian Janikowski Salute to Service Jersey . The defence is doing its part, too. Drew Brees threw a pair of touchdown passes in the first half and the guys on the other side made sure that was enough, sending the Saints to a 17-13 victory over the Atlanta Falcons on Thursday night. http://www.theraidersnflstore.com/nike-khalil-mack-black-jersey/ . Perhaps Carroll was so prepared for a break because he believes there is very little the Seattle Seahawks need heading into the off-season. "I dont see anything that we need to add. We just have to get better," Carroll said.LONDON -- Just as it did last weekend at Anfield, Liverpool got off to a flying start against Arsenal. But this time, the Gunners weathered the storm. Arsene Wengers team was on the ropes in the early stages of a lively FA Cup tie, until Alex Oxlade-Chamberlain scored a goal against the run of the play. His strike shifted the momentum in the hosts favour and he set up another for Lukas Podolski as Arsenal won 2-1 to advance to the quarterfinals on Sunday. Following their 5-1 thrashing at Anfield in the Premier League, when they conceded four goals in the opening 20 minutes, the Gunners got their revenge after surviving another sustained period of Liverpool pressure in the second half. They will next face Everton at home after the Toffees booked their place with a 3-1 defeat of Swansea, while Manchester City will face Cup holder Wigan in a rematch of last years final. "The intensity of the performance pleased me, I am very proud of the way we responded to the huge defeat that we had last week," said Arsenal manager Arsene Wenger, chasing his first piece of silverware since the 2005 FA Cup. Liverpool again looked the stronger team in the early stages. A superb through ball from Steven Gerrard found Daniel Sturridge, but the England strikers low shot was parried away by keeper Lukasz Fabianski. Luis Suarezs flicked pass then picked out Sturridges run behind Per Mertesacker, but Fabianski forced him to shoot wide. "I thought the best team lost. I thought the very least we deserved was a replay," Liverpool manager Brendan Rodgers said. "We probably should have been 2-0 up inside those first six or seven minutes. Going forward we were outstanding. Im disappointed with the goals, the first one in particular was just a long ball into the box." Though Arsenal struggled to keep the ball, Oxlade-Chamberlain put the home side ahead after Liverpool failed to clear a free kick. Yaya Sanogo, making his first start for Arsenal, saw his shot blocked by Gerrard but the ball rebounded for Oxlade-Chamberlain, who confidently slotted home from close range past Brad Jones in the 16th minute. Arsenal was sharper on the ball after the goal but Liverpool remained dangerous on the break, with Suarez combining well with Sturridge on a swift counterattack. Raheem Sterling then showed his speed and technique down the left flank, rounding Carl Jenkinson before his tired effort from a narrow anglle was diverted away for a corner. Charles Woodson Salute to Service Jersey. Suarez had two more opportunities to put his team level before halftime but Fabianski, having a superb game, dived well to deny his low shot before the Uruguay striker missed the target with a chip from the edge of the box. Suarez went close immediately after the interval when he almost beat Fabianski with a low shot that forced the keeper into a fine reflex save. Arsenal doubled its lead on the next move, a slick-passing counterattack concluded by Podolski, who scored with a clean finish from Oxlade-Chamberlains cutback in the 47th. Arsenal then had a good spell of possession but, after Suarez unleashed a powerful volley over the bar and Mesut Ozil threatened Jones with a low shot, the Uruguay striker won a penalty when Podolski clumsily clipped his ankle in the box. Gerrard coolly converted from the spot to pull one back, sending Fabianski the wrong way in the 59th minute. Suarez was jeered by Arsenal supporters when he went down after a hefty collision with Oxlade-Chamberlain in the box with 26 minutes to go. Referee Howard Webb ignored the visitors appeals for another penalty. Substitute Santi Cazorla should have restored Arsenals two-goal lead in the 73rd when he thumped a volley far over the bar while unmarked from the edge of the box. Daniel Agger had Liverpools best chance to make it 2-2 in the 87th minute, but his header following a free kick from Gerrard just drifted over the top. At Goodison Park, substitute Steven Naismith scored a goal and won a penalty. With the score level at 1-1, Everton manager Roberto Martinez opted for experience when he made a double substitution on the stroke of the hour, with Naismith and Leon Osman replacing Lacina Traore and Ross Barkley. The move paid off as Naismith took full advantage of Neil Taylors back pass to slide the ball into the bottom corner in the 65th minute. Everton was then awarded a penalty after Jazz Richards fouled Naismith, with Leighton Baines converting. Traore had put Everton ahead, back-heeling into the net from close range in the fourth minute before Jonathan de Guzman equalized. Chris Porter scored twice in stoppage time as Sheffield United also advanced by beating Nottingham Forest 3-1. There will be a non-Premier League side in the semifinals as third-tier United will either take on second-division sides Sheffield Wednesday or Charlton Athletic in the last eight. 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